中国医学文摘·耳鼻咽喉科学杂志

Effect of acupuncture on the ultrastructure of neurons and astrocytes in the hippocampal dentate gyrus in rats with Alzheimer’s disease induced by Aβ1-42

关键词：the    ultrastructure    of    neurons    and    astrocytes    disease    induced    by    a    alzheimer    

Objective To observe the effects of acupuncture at'Baihui'(GV 20) and'Shenshu'(BL 23) on the ultrastructure of hippocampal dentate gyrus in rats with Alzheimer’s disease. Methods Forty SPF Wistar male rats were randomly divided into normal group,sham operation group,model group and acupuncture group,10 rats in each ...

Effect of transcutaneous electrical acupoint stimulation on recovery of gastrointestinal function after cesarean section

关键词：effect    transcutaneous    electrical    acupoint    stimulation    gastrointestinal    function    

Objective To explore the effect on the recovery of gastrointestinal function after cesarean setion treated with transcutaneous electrical acupoint stimulation at Zusanli(ST 36) on the basis of routine treatment. Methods A total of 110 primiparas after cesarean section were randomized into observation group and contro...

Effect of moxibustion at “Guanyuan”( CV4) and “Sanyinjiao”( SP 6) on bone morphology,metabolism and ERα of bone marrow mesenchymal stem cells in the ovariectomized rats

关键词：on    bone    morphology    metabolism    and    er    cv4    effect    of    moxibustion    guanyuan    sanyinjiao    marrow    mesenchymal    stem    cells    

Objective To observe the effects of moxibustion at'Guanyuan'(CV 4) and'Sanyinjiao'(SP 6) on bone morphology,metabolism and ERαof bone marrow mesenchymal stem cells (MSCs) in the ovariectomized rats and explore the underlying mechanism of moxibustion at Guanyuan (CV 4) and Sanyinjiao (SP 6) on the regulationof bone me...

A controlled study on the therapeutic effect of acupuncture and acupuncture combined with drugs on peripheral facial paralysis with normal result of facial nerve magnetic resonance examination

关键词：the    therapeutic    effect    acupuncture    and    combined    with    drugs    facial    paralysis    

Objective To explore whether a combination of drugs is needed when acupuncture is used to treat peripheral facial paralysis with normal result of facial nerve magnetic resonance examination. Methods A total of 48 normal facial nerve magnetic resonance examination of peripheral facial paralysis patients were randomly ...

Effects of Serum Containing Tongfengning on the expression of NALP3 inflammasome related proteins and inflammatory cytokines in THP-1 induced by uric acid

关键词：thp    effects    of    serum    containing    tongfengning    nalp3    inflammasome    related    proteins    

Objective To explore the anti-inflammatory mechanism of Tongfengning on gouty arthritis by detecting the effects of serum containing Tongfengning on the expression of NALP3 inflammasome related protein and mRNA and the levels of IL-1β,PGE2 in human monocytic cell line THP-1 induced by monosodium urate ( MSU ).

Comparative studty on effects of Yiqi Yangxue decoction and Buzhong Yiqi decoction containing serums with Radix Hedysari or Radix Astragali on immunologic function of SAMP8 mice splenic lymphocytes

关键词：comparative    studty    yiqi    yangxue    decoction    immunologic    function    of    samp8    mice    splenic    lymphocytes    

Objective To compare the different effects between Yiqi Yangxue and Buzhong Yiqi decoction containing serums with Radix Hedysari or Radix Astragali on immunologic function of SAMP8 mice splenic lymphocytes.Methods Fifty young Kunming mice were randomly divided into 5 groups:Yiqi Yangxue Decoction with Radix Hedysari ...

Effects of Yiqi Yangyin Quyu recipe containing serum on AQP5 and M3R of human submandibular gland cells with sj?gren’s syndrome

关键词：aqp    human    submandibular    gland    cells    hsg    

Objective To observe effect of Yiqi Yangyin Quyu recipe (YYQR) containing serum on aquaporin protein-5(AQP5) and type 3 muscarinic acetylcholine receptors(M3R) of human submandibular gland cells with Sj?gren’s syndrome(SS). Methods YYQR containing serum was prepared.

Observation on the effect of Yangyin Yiqi Huoxue Lishui compound combined with intravitreal injection of Conbercept in the treatment of Diabetic macular edema

关键词：observation    on    the    effect    yangyin    yiqi    huoxue    lishui    injection    of    conbercept    

Objective To observe the effect of Yangyin Yiqi Huoxue Lishui Compound (YYHLC) combined with intravitreal injection of conbercept in the treatment of diabetic macular edema. Methods Sixty patients (70 eyes)with diabetic macular edema were randomly assigned to treatment group (30 cases,36 eyes) and control group(30 ca...

A clinical study of Dangua Humai oral liquid on cardiovascular risk factors among patients with type 2 diabetes mellitus

关键词：a    clinical    study    dangua    humai    oral    liquid    patients    with    type    

Objective To study the influence of Dangua Humai oral liquid on inflammatory markers and cardiovascular prognosis among patients with high cardiovascular risks of type 2 diabetes mellitus. Methods A sample of 70 participants were randomly assigned to an experimental group(35 cases) and a control group(35 cases).

Compound Daxueteng Enemas Combined with GnRH-a on Endometriosis after Laparoscopic Surgery: a clinical research

关键词：daxueteng    enemas    on    endometriosis    after    laparoscopic    surgery    a    clinical    research    

Objective To evaluate the effect of Compound Daxueteng Enemas combined with gonadotropin-releasing hormone agonists (GnRH-a) on endometriosis (EMs) after laparoscopic surgery. Methods From January 2015 to March 2017,65 EMs cases of blood and heat accumulationsyndrome undergoing laparoscopic conservative surgeryin Zhe...

Clinical observation of Yiqi Yangyin Hexue decoction in treating patients with chronic primary immune thrombocytopenia

关键词：clinical    observation    yiqi    yangyin    hexue    decoction    plt    

Objective To evaluate the 8-week comprehensive effect of Yiqi Yangyin Hexue decoction (YYHD) in adult patients with chronic primary immune thrombocytopenia (cITP). Methods Totally 76 patients from the department of hematology of Affiliated Hospital of Nanjing University of Chinese Medicine were enrolled.

Disease flare patterns and predictors of lupus nephritis recurrence by Chinese and Western medicine

关键词：sledai    western    disease    flare    patterns    

Objective To analyze the scores of Chinese medicine (CM) symptoms,laboratory indices,the level of urinary vascular cellular adhesion molecule-1 (VCAM-1) and Periostin in patients with lupus nephritis (LN),and to investigate their potential feasibility to be the predictor for LN.

Effect of Huoxue Jiedu Recipe on the Apoptosis and Cytokine in Diabetic Retinopathy

关键词：effect    of    huoxue    jiedu    recipe    apoptosis    in    diabetic    retinopathy    

Objective To observe the effects of Huoxue Jiedu Recipe(HXJD) on the apoptosis and the expression of NF-_κB and Caspase-3 in the reina tissue of early diabetic rats. Methods The diabetic rat model was established by using one single intraperitoneal injection of streptozotocin (STZ,65 mg /kg).

Abnormal mitochondrial fusion and fissionin PBDE-47-induced change in mitochondrial mass in PC12 cells

关键词：pc    abnormal    mitochondrial    fusion    pc12    cells    

Objective To investigate the effect of 2,2’,4,4’-tetrabromodiphenyl ether (PBDE-47) on the mitochondrial mass in rat adrenal pheochromocytoma (PC12)cells and the potential mechanisms. Methods Highly differentiated PC12 cells were divided into control,1,10 or20μmol/L PBDE-47-treated groups and cultured for 24 h.

Effects of new Tongguan Granule( Qimai Tongguan Formula) on heart failure after acute myocardial infarction: a randomized controlled trial

关键词：bnp    ntg    qimai    tongguan    formula    a    randomized    controlled    trial    

Objective To observe the effects of New Tongguan Granule (NTG,Qimai Tongguan Formula) in treatment of heart failure patients after acute myocardial infarction.Methods A prospective randomized double-blinded controlled trial was conducted. Totally 60 patients with heart failure after acute myocardial infarction were r...

Preliminary analysis of differential expression of miRNA-423-5p and miRNA-26a-5p in lung tissue of early silicotic rats

关键词：mirna    preliminary    analysis    lung    tissue    of    early    silicotic    rats    

Objective To screen the changes of microRNA(miRNA) expression profiles in lung tissues of early silicosis rats,and provide a basis for functional analysis of differential microRNA. Methods SPF Wistar male rats were randomly divided into negative control group and SiO2-exposed groups,with 30 rats in each group.

Construction of 3β-HSD gene silencing cell line and its effects on apoptosis induced by DEHP

关键词：hsd    gene    silencing    cell    line    apoptosis    induced    by    dehp    construction    of    3    

Objective To construct 3β-HSD gene shRNA lentivirus interference vecto,then transfect into human MCF-7 cells,and construct cell line with 3β-HSD gene silencing,finally to study the effects of 3β-HSD on apoptosis induced by di-(2-ethylhexyl) phthalate (DEHP).Methods According to the mRNA sequence of 3β-HSD gene provid...

The preliminary study on the combined application model of serum miRNAs in the diagnosis of pneumoconiosis

关键词：mirnas    the    combined    application    model    serum    

Objective To explore the role of serum microRNA(miRNAs) levels in the detection of pneumoconiosis,and to establish a combined application model of multiple serums miRNAs for pneumoconiosis diagnosis. Methods152 cases were selected in case group and control group respectively.

Effects of three MAPK inhibitors on the expressions of TGF-β1 and α-SMA mRNA and protein in LX-2 cells induced by sodium arsenite

关键词：effects    three    mapk    inhibitors    sma    mrna    cells    

Objective To investigate the effects of three mitogen-activated protein kinase (MAPK) inhibitors on the expressions of transforming growth factor-β1 (TGF-β1),α-smooth actin (α-SMA) mRNA and protein in human liver stellate cells (LX-2 cells) activated by sodium arsenite.

Changes in mass spectrometry of proteins in patients with 1-bromopropane poisoning after treatment

关键词：changes    spectrometry    of    proteins    poisoning    after    treatment    

Changes and significance of the ratio of T helper 17 and regulatory T cell in peripheral blood of patients with coal-burning-borne arsenic poisoning

关键词：changes    significance    the    ratio    of    t    helper    17    arsenic    poisoning    

Objective To observe the change of T helper 17(Th17),regulatory T cell (Treg) as a percentage of lymphocytes and the Th17/Treg ratio in peripheral blood of patients with coal-burning-borne arsenic poisoning,and to explore the role of Th17 cells and Treg cells balance in arsenic-induced immune injury.

Differential expression and significance of Foxp3,TGF-β1 and IL-2 in peripheral blood of patients with coal-burning arsenic poisoning

关键词：differential    expression    foxp3    tgf    il    

91-95.Objective To investigate the expression of transcriptionfactor forkhead /winged helix transcription factor 3(Foxp3),immune factor transforming growth factor-beta1 (TGF-β1),and T-lymphocyte activation related factorinterleukin-2 (IL-2) in peripheral blood of patients withcoal-burning arsenic poisoning,and to ana...

Effects of excessive fluoride on osteocalcin and glucose metabolism in mice

关键词：effects    excessive    fluoride    glucose    metabolism    

Objective To observe the effects of excessive fluorideon osteocalcin and glucose metabolism in mice.Methods Thirty-two male C57 mice ( body mass: 18-24 g) were selected as study subjects which were randomizedinto four groups (8 mice in each group) accordingto their body mass by random number table method:0 mg /L grou...

Effect of fluoride on expression of phosphorylated NMDAR protein in rat hippocampal neurons

关键词：nmdar    effect    phosphorylated    protein    rat    hippocampal    neurons    

Objective To observe the expression of phosphorylatedN-methyl-D-aspartate receptor ( P-NMDAR) proteinin hippocampal neurons of rats with fluorosis and explorethe mechanism of neuronal damage caused by fluorosis.Methods Sixteen Sprague-Dawley rats within 24 h afterbirth were selected,and hippocampus of the brain wasis...

Status of iodine nutrition in pregnant women in Foshan City, Guangdong Province in 2017

关键词：guangdong    province    in    2017    iodine    nutrition    foshan    city    

Objective To study the iodine nutritional status ofpregnant women in Foshan City,Guangdong Province,and to provide basis for iodine supplementation scientificallyfor them. Methods In 2017, five districtsChancheng,Nanhai,Shunde,Sanshui and Gaoming inFoshan were selected. Each monitoring site was dividedinto five secti...

Study on the effect of different water-improving projects and different water-improving years on children’s dental fluorosis in Tianjin

关键词：different    projects    years    dental    fluorosis    tianjin    

Objective To investigate the influence of differentwater-improving defluoridation projects and different water-improving years on children's dental fluorosis,and toprovide a scientific basis for further defluoridation ofdrinking water. Methods Totally one fourth of endemicfluorosis villages in all agricultural-relate...

Analysis of total fluoride intake for persons over 16 years old in historic heavier illness villages of coal-burning-borne endemic fluorosis areas in Guizhou Province

关键词：analysis    total    fluoride    intake    for    persons    illness    villages    guizhou    province    

Objective To understand the status of total fluorideintake for persons over 16 years old after implementationof comprehensive prevention and control measures in historicalsevere diseased areas of coal-burning-borne endemicfluorosis in Guizhou Province. Methods In 2017,a total of 3 villages were selected as survey sit...

Clinical characteristics and T-lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections

关键词：cmv    clinical    characteristics    subsets    48    acquired    immune    deficiency    syndrome    patients    cytomegalovirus    infections    

Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with human immunodeficiency virus (HIV)-1 /AIDS and CMV infections were recruited at Peking UnionMedical C...

Clinical application of neutrophil-to-lymphocyte ratio in predicting the prognosis of H7N9 avian influenza

关键词：clinical    application    h7n9    avian    influenza    plr    

Objective To explore the predictive value of neutrophil-to-lymphocyte ratio on the prognosis of H7N9 avian influenza. Methods A retrospective analysis was conducted on 28 H7N9 avian influenza patients (treatment group) at the First Affiliated Hospital of Soochow University from April 2013 to January 2016.

Relationship between insertion/deletion polymorphism of angiotensin converting enzyme gene and type 2 diabetic kidney disease

关键词：relationship    polymorphism    enzyme    gene    type    2    diabetic    kidney    disease    

Objective To explore the interaction of angiotensinconverting enzyme (ACE) insertion /deletion(I /D) polymorphism( rs1799752 ) with diabetic kidney disease(DKD) development as well as its interaction with smokingand obesity in Chinese type 2 diabetic mellitus(T2DM) using an improved experiment method. MethodsFrom Jun...

Analysis of CYP21A2 gene mutation and phenotype in patients with 21-hydroxylase deficiency

关键词：cyp    analysis    of    cyp21a2    gene    mutation    deficiency    

Objective To investigate the spectrum of CYP21A2gene mutation and the correlation between genotype and phenotype in patients with 21-hydroxylase deficiency in Tianjin and surrounding areas. Methods Genomic DNA was extracted from the peripheral blood samples of the proband.

Analysis of extreme obesity in two pedigrees due to leptin receptor mutation

关键词：bmi    analysis    extreme    obesity    leptin    receptor    mutation    

Objective This study reported two extremly obesewomen who underwent metabolic surgery due to their mutationsin leptin receptor ( LEPR). Genomic DNA wasextracted from the anticoagulant blood samples of the twopatients and their parents. A panel of genes related tometabolic diseases or whole exon sequencing wasscreened...

Association of serum CMPF level with fatty acid metabolism and obesity in community population

关键词：dfo    association    serum    cmpf    level    fatty    acid    metabolism    community    population    

Objective To detect the serum level of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF),a significant metabolite of fish oil,in subjects with normal glucose tolerance (NGT) in local communities,and to investigate the association of CMPF with fatty acid metabolism.Methods A total of 272 NGT participants fromsc...

Screening and validation of type 2 diabetes mellitus related circRNAs

关键词：screening    validation    of    type    2    diabetes    circrnas    

Objective To explore circular RNAs ( circRNAs)which were associated with type 2 diabetes mellitus(T2DM) and validate their clinical significance. MethodsCircRNAs profiling microarray and bioinformaticsmethods were performed to detect insulin-signaling-pathway-related circRNAs,including hsa_circ_ 0056891,hsa_circ_ 006...

Association between Gln223Arg polymorphism in leptin receptor gene and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

关键词：nafld    association    gln223arg    polymorphism    type    2    diabetes    mellitus    gln    

Objective To explore the relationship between Gln223Arg polymorphism in leptin receptor gene(LEPR) and nonalcoholic fatty liver disease (NAFLD)in patients with type 2 diabetes mellitus (T2DM).Methods A total of 234 hospitalized patients with T2DM in the Department of Endocrinology in the Affiliated Hospital of North ...

NGS-based gene targeting panel design of type 2 diabetes susceptible genes and its clinical application

关键词：gene    type    2    diabetes    susceptible    genes    clinical    application    

Objective To design amplicons-based target sequencing panels using high-throughput next generation sequencing (NGS) and multiplex PCR techniques to sequence type 2 diabetes susceptibility genes and to assess their relationship with clinical characteristics in patients with type 2 diabetes.

Effect of CHOP siRNA on mRNA expression of PERK-ATF4-CHOP pathway in diabetic peripheral neuropathy rats

关键词：chop    sirna    mrna    expression    pathway    neuropathy    rats    atf    

Objective To investigate the effect of C/EBP homologous protein (CHOP) on mRNA expressions of RNA-dependent protein kinase-like ER kinase (PERK)-activating transcription factor 4 (ATF4)-C/EBP homologous protein (CHOP) pathway in diabetic peripheral neuropathy(DPN) rats. Methods 48 SD male rats werefed with high-fat d...

Effects of intrauterine exposure to thyroid dysfunction on the development of brain neurons in neonatal rats

关键词：ptu    thyroid    dysfunction    brain    neurons    neonatal    rats    pnd    

Glucagon-like peptide-1 regulates lipid metabolism in hepatocytes through Foxo1/3

关键词：nafld    glp    

Objective Glucagon-like peptide-1 ( GLP-1 ) hasbeen reported to be effective in the treatment of nonalcoholicfatty liver disease (NAFLD). However,the molecularmechanism of GLP-1 on NAFLD is remained unclear.The present study was to detect whether the effectof GLP-1 on triglyceride (TG) content in hepatocytes isdepend...

Value of fibrinogen to albumin ratio on predicting spontaneous recanalization of infarct-related artery in patients with acute ST-segment elevation myocardial infarctionl

关键词：stemi    albumin    ratio    acute    elevation    myocardial    infarctionl    ira    

Objective To investigate the value of fibrinogen toalbumin ratio (FAR) at admission on predicting spontaneousrecanalization of infarct-related artery ( IRA) inpatients with acute ST-segment elevation myocardial infarction( STEMI ). Methods Clinical data from 255acute STEMI patients ((61. 1 ± 11. 2) years old,189males...