Cancer Biology & Therapy

Journal Title：Cancer Biology & Therapy

Cancer, the second leading cause of death, is a heterogenous group of over 100 diseases. Cancer is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death with the ability to survive under stresses of nutrient and growth factor deprivation, hypoxia, and loss of cell-to-cell contacts. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells. The phenotype includes genomic instability and chromosomal aneuploidy that allows for acceleration of genetic change. Malignant transformation and tumor progression of any cell requires immortalization, loss of checkpoint control, deregulation of growth, and survival. A tremendous amount has been learned about the numerous cellular and molecular genetic changes and the host-tumor interactions that accompany tumor development and progression. It is the goal of the field of Molecular Oncology to use this knowledge to understand cancer pathogenesis and drug action, as well as to develop more effective diagnostic and therapeutic strategies for cancer. This includes preventative strategies as well as approaches to treat metastases. With the availability of the human genome sequence and genomic and proteomic approaches, a wealth of tools and resources are generating even more information. The challenge will be to make biological sense out of the information, to develop appropriate models and hypotheses and to translate information for the clinicians and the benefit of their patients. Cancer Biology & Therapy aims to publish original research on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. We will include timely reviews covering the broad scope of the journal. The journal will also publish op-ed pieces and meeting reports of interest. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The journal and the outstanding Editorial Board will strive to maintain the highest standards for excellence in all activities to generate a valuable resource.

癌症是第二大死亡原因，是一类由 100 多种疾病组成的异质性疾病。癌症的特征是细胞和基质增殖紊乱和失调，伴随细胞死亡减少，在营养和生长因子缺乏、缺氧和细胞间接触丧失的压力下仍能存活。在分子水平上，癌症是一种遗传性疾病，是由于体细胞中突变随时间积累而发展起来的。其表型包括基因组不稳定性和染色体非整倍性，这加速了基因变化。任何细胞的恶性转化和肿瘤进展都需要永生化、检查点控制丧失、生长失调和存活。人们对伴随肿瘤发展和进展的众多细胞和分子遗传变化以及宿主-肿瘤相互作用有了大量的了解。分子肿瘤学领域的目标是利用这些知识来了解癌症的发病机制和药物作用，以及开发更有效的癌症诊断和治疗策略。这包括预防策略以及治疗转移的方法。随着人类基因组序列以及基因组和蛋白质组学方法的出现，大量的工具和资源正在产生更多的信息。挑战在于从信息中得出生物学意义，开发适当的模型和假设，并为临床医生和患者提供信息。《癌症生物学与治疗》旨在发表关于癌症分子基础的原创研究，包括与诊断或治疗具有转化相关性的文章。我们将及时发表涵盖期刊广泛范围的评论。该期刊还将发表感兴趣的评论文章和会议报告。目标是通过使用传统和电子格式及时发表重要结果来促进沟通和快速信息交换。该期刊和优秀的编辑委员会将努力在所有活动中保持最高的卓越标准，以产生宝贵的资源。

Cancer Biology & Therapy创刊于2002年，由Landes Bioscience出版商出版，收稿方向涵盖医学 - 肿瘤学全领域，此期刊水平偏中等偏靠后，在所属细分领域中专业影响力一般，过审相对较易，如果您文章质量佳，选择此期刊，发表机率较高。平均审稿速度 约2.3月 ，影响因子指数4.4，该期刊近期没有被列入国际期刊预警名单，广大学者值得一试。