Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis

Journal Title：Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis

Mutation Research (MR) provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs.

MR publishes articles in the following areas:

Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.

Mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing.

Landscape of somatic mutations and epimutations in cancer and aging.

Role of de novo mutations in human disease and aging; mutations in population genomics.

Interactions between mutations and epimutations.

The role of epimutations in chromatin structure and function.

Mitochondrial DNA mutations and their consequences in terms of human disease and aging.

Novel ways to generate mutations and epimutations in cell lines and animal models.

突变研究 (MR) 提供了一个平台，用于发布 DNA 突变和表观突变的各个方面，从基本的进化方面到遗传和表观遗传诊断和治疗中的转化应用。突变被定义为 DNA 序列和序列组织的所有可能改变，从点突变到基因组结构变异、染色体畸变和非整倍性。表观突变被定义为表观基因组的改变，即 DNA 甲基化、组蛋白修饰和小调节 RNA 的变化。

MR 在以下领域发表文章：

特别令人感兴趣的是 DNA 损伤和突变影响发育和分化、干细胞生物学和细胞命运的基本机制，包括各种形式的细胞死亡和细胞衰老。

人类分子流行病学中基因组不稳定性的研究以及与人类疾病等复杂表型的关系被认为是一个日益重要的领域。

（表观）突变诱导机制，例如在 DNA 修复、复制或重组过程中；检测（表观）突变的新方法，重点是超高通量测序。

癌症和衰老中的体细胞突变和表观突变概况。

新生突变在人类疾病和衰老中的作用；群体基因组学中的突变。

突变和表观突变之间的相互作用。

表观突变在染色质结构和功能中的作用。

线粒体 DNA 突变及其对人类疾病和衰老的影响。

在细胞系和动物模型中产生突变和表观突变的新方法。

Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis创刊于1964年，由Elsevier出版商出版，收稿方向涵盖生物 - 毒理学全领域，此期刊水平偏中等偏靠后，在所属细分领域中专业影响力一般，过审相对较易，如果您文章质量佳，选择此期刊，发表机率较高。平均审稿速度 偏慢,4-8周 ，影响因子指数1.5，该期刊近期没有被列入国际期刊预警名单，广大学者值得一试。